Endocrine Abstracts

75 male was referred to endocrine service with incidental pituitary macroadenoma measuring 4.2×3.1×3.3 cm noted on MRI-C-Spine done for ankylosing spondylitis with Atlanto-axial joint instability. He had reduced secondary sexual characteristics and left quadrantanopia. Endocrine studies confirmed thyrotroph and gonadotroph failure but normal lactotroph and HPA axis. He underwent trans-sphenoidal tumour resection followed by external beam radiation due to tumour resid...

Cyclophosphamide is an alkylating agent used in the treatment of malignant and autoimmune diseases. Severe hyponatraemia is a serious electrolyte disorder with life threatening neurological sequelae. We report a case of recurrent severe, symptomatic hyponatraemia that developed in a 61 year old female with systemic vasculitis and Sjogrens syndrome following low-dose cyclophosphamide.Case report: A 61 year old lady, with ANA positive systemic vasculitis p...

Introduction: An important part of diabetes management is maintaining high standards of in-patient care. A previous audit in the south of England demonstrated difficulties consistently achieving standards identified as good practice. This audit aimed to identify current standards of in-patient care provided to children with type 1 diabetes across the Yorkshire and Humber region.Methods: The audit was conducted against in-patient care standards identified...

Introduction: Achieving optimum glycaemic control in young adults is challenging. Furthermore, transfer of care to adult services has been associated with deterioration in glycaemic control. We aimed to establish glycaemic control and rate of microvascular complications in young adults with childhood onset type 1 diabetes (T1D) and looked specifically at a subset of patients before and after transfer to adult care.Methods: A retrospective study of patien...

Background: Suboptimal glycaemic control in hospital inpatients is related to poor clinical outcomes and longer hospital stay. The aims of this study were to document the prevalence and severity of hypo- and hyperglycaemia in medical inpatients and to evaluate aspects of patient management and staff proficiency regarding glucose management.Methods: We performed a retrospective review of 21 381 capillary blood glucose results in 1496 unique patients on 26...

Background: At diagnosis of diabetes is a critical time in the life course of diabetes. This a critical time for patient take on knowledge and using it (ref). Utilisation of this information is suboptimal due to logistical factors such as ward environment, time constraints of staff, psychological impact of the diagnosis. Current models of education are mainly didactic with limited impact in some patients.Aims: In collaboration with demontfort design unit...

Background: There is an increased incidence of Type 1 diabetes in preschool children and the management of diabetes in this group is challenging. Preschool children are dependent on others for all aspects of their care. Normoglycaemia in preschool children reduces the likelihood of acute and chronic complications.Objectives: Our goals were to:1. Outline the demographic characteristics of children diagnosed with diabetes before 5 ye...

Introduction: A case series of three children diagnosed with MODY at a university hospital between November 2015 and May 2018. All of them was found to have HNF1B mutation.Background: HNF1β-MODY (MODY5) is a rare form of monogenic diabetes that is often associated with a wide range of urinary tract anomalies including renal cysts. It’s a dominantly inherited disease including maturity-onset diabetes of the young (MODY), pancreatic insufficiency...

Background: The overnight dexamethasone (DEX) suppression test is useful for the investigation of hypercortisolism, however several factors may influence its performance. Intestinal uptake of DEX, inactivation by conversion by CYP3A4 in the liver and renal clearance can all affect test variability. It is also known that several drugs can either reduce or accelerate CYP3A4 activity, thereby affecting blood DEX concentrations. Interpretation of the test would be greatly enhanced...

We present two patients with significant hypokalaemia initially attributed to liquorice use.Case 1: A 52-year-old engineer was noted to have a potassium level of 2.5 mmol/l (3.5–5.3 mmol/l) at a Well Man check-up. He had no significant past history, and took no medications. He was normotensive. The patient reported regular liquorice use. The hypokalaemia corrected with supplementation equivalent to 48 mmol K+ daily, and with cessation of ...